Prof Afif EL-Khuffash

  • Consultant Neonatologist, Rotunda Hospital
  • Clinical Professor, RCSI


Prof EL-Khuffash is a Consultant Neonatologist at the Rotunda Hospital in Dublin, Ireland. His primary clinical and research area of expertise is the assessment heart function in term and preterm neonates. He is the lead for neonatal echocardiography and heart function assessment in the neonatal intensive care unit in the Rotunda Hospital.

Prof EL-Khuffash completed a fellowship in neonatal cardiology in Our Lady’s Children’s Hospital, Crumlin. He has explored the use of novel technology in monitoring the cardiovascular function of preterm and sick term infants and was part devising the only neonatal echo training course in Canada. He co-devised the world’s first echo teaching website and mobile device app. Recently, Prof EL-Khuffash has assumed a leadership role at a European level in devising training guidelines for echocardiography by the Neonatologist. He is the lead editor of the Haemodynamic Module in the NOTE project, offering a new international online Masters level educational programme in neonatal medicine as collaboration between the European Society for Neonatology (ESN) and the Faculty of Health Sciences at the University of Southampton.

Prof EL-Khuffash graduated from Trinity College, Dublin in 2002 and enrolled in the Royal College of Physicians of Ireland paediatric specialist training scheme in 2005. He completed a Doctor of Medicine (MD) degree in University College, Dublin in 2008 and his neonatal specialty training in Toronto, Canada (2009-2011). Following this, he was appointed as a consultant Neonatologist and Assistant Professor of Paediatrics at the University of Toronto in January of 2011. He obtained a diploma in clinical epidemiology during his time in Toronto.

He is the recipient of several national and international research awards, with international peer reviewed publications and keynote presentations and the lead for cardiovascular research, supervising several post graduate PhD candidates.


Reply to correspondence.
El-Khuffash A, McNamara P.J Perinatol. 2021 Nov 2. doi: 10.1038/s41372-021-01235-y. Online ahead of print.PMID: 34728824 No abstract available.

Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes.
O’Dea MI, Kelly LA, McKenna E, Strickland T, Hurley TP, Butler J, Vavasseur C, El-Khuffash AF, Miletin J, Fallah L, White A, Wyse J, Molloy EJ.Front Pediatr. 2021 Oct 12;9:734540. doi: 10.3389/fped.2021.734540. eCollection 2021.PMID: 34712631 Free PMC article.

Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade.

O’Reilly D, Murphy CA, Drew R, El-Khuffash A, Maguire PB, Ainle FN, Mc Callion N.Pediatr Res. 2022 Jan;91(2):359-367. doi: 10.1038/s41390-021-01715-z. Epub 2021 Oct 28.PMID: 34711945 Review.